This series contains four subseries. The first is Correspondence, which includes family correspondence among various branches of the Drury and related families, generally centered around Luke. It also contains business correspondence, again mainly Luke's, dealing with his farm and mill, and especially with loans to and from local people. Those appearing frequently include the Adams, Bachelor, Prentice and Rice families in Grafton, as well as the Brooks, Chase and Turner families, related to the Drurys by marriage. There is also a series of letters dealing with the estate of Timothy Darling, of which Luke was executor.

The second subseries comprises Financial Papers. These are mainly Luke's bills and receipts, and his notes on personal loans. A batch of small account books deals with milling, while another contains notations of fur trapping. A third, dated 1802, is a list of Luke's notes of hand. There are also papers from estate valuations and sales. One details the estate of "PerryGreen" [Peregrine) Howland, who was probably a relative of Luke's second wife Mary Howland Drury. The other papers are not clearly identified, but they seem to be from the estates of Timothy Darling, Luke Jr. (d.1790), and Luke Sr. (d.1811).

A third subseries, Legal Papers, contains various documents. Besides deeds and conveyances, it includes powers of attorney, papers establishing guardianship, and warrants to Luke Drury as deputy sheriff. There are also papers from specific legal actions. These include one case (Perkins v. Thompson, 1820-26) which does not seem to be related to the Drurys.

Subseries 4, Miscellaneous Papers, includes military documents for both Luke and his son Ephraim. There are also medical lectures which were probably noted by either Luke Jr. or his brother John, both of whom became doctors. The series also contains prescriptions and recipes, including one for "strong bear" (beer).

Subseries 1 contains the papers of Timothy Darling, who was not actually related to the Drurys. He and Luke were both prominent in Grafton affairs, and the two shared business connections. In addition, Luke executed Darling's will, a lengthy process involving at least one lawsuit. The documents in this subseries deal with business; the majority are notes of hand. The Goulding papers, Subseries 2, also concentrate on business, though they include military papers as well. Israel Goulding married Luke's daughter Lucy. His brothers Jonah, John, Joshua and Ephraim also appear. The Place papers, Subseries 3, deal mainly with financial matters. It has so far been impossible to trace this family, but there was at least a business connection with the Drurys. The Shermans, Subseries 4, were connected with the Drurys by marriage as well as business. Their papers include leases as well as notes of hand, bills, and receipts. They represent Thankful Temple Sherman (Luke's mother-in-law), her sons Moses, David, and Aaron, and her nephew Timothy.

This large series has been divided into three subseries. The first, Town Papers, includes correspondence to and from the selectmen, appointments and warrants for town positions (especially the highway survey and repair committees). It also includes documents relating to the 1786 county convention where Luke Drury, as one of Grafton's representatives, clearly supported the demands and concerns of the Shaysite rebels. Subseries 2 deals with taxes. It contains tax documents, mainly warrants to Luke Drury and other tax collectors. The tax records show collections for highway, town, state, minister, and county taxes. In addition, there are valuations of real estate and personal property. There are individual assessments for taxation. Also included is a complete tax list for 1794, presumably listing every taxpayer in Grafton. The third subseries contains the papers of Grafton families, again including the Adams, Bachelor, Brooks, Chase, Prentice and Rice families. Like the Drury papers, these range from business to legal, containing few personal papers. The people represented here had some connection, business or otherwise, with the Drurys.

This series consists of fragments and scratch papers, some of which can be identified, but none of which can be reconstructed.