Zephaniah Buffington (born 1771) was a farmer and merchant active in Dartmouth, Massachusetts. His business connections appear to have been principally within the Society of Friends communities of Bristol County, Massachusetts and Washington County, New York, the latter being a community started by emigrants from the Dartmouth area. As a merchant within this Quaker network, Buffington had dealings with other prominent Bristol County Quakers, including Joel Packard, Stephen Gifford, Peleg Slocum, and Joseph Howland and Company. Furthermore, his one marriage in the Dartmouth vital statistics was to Lydia Tucker, the daughter of another Dartmouth Quaker family; she died within two years of the wedding.