The Albert Francis Blakeslee Papers contain biographical material on Blakeslee and his career both before and at Smith College; correspondence with fellow botanists; manuscripts notes of various publications; and family photographs, professional photographs, and conference participant photographs. The publications span his career and consist of numerous articles and short publications written by Blakeslee from 1913 through 1953 on an assortment of scientific topics with a focus on botany, as well as manuscripts of seminars and talks given by him. His talks include information and manuscripts from talks given by Blakeslee at the Botanical Society of America and a talk given to Smith College faculty on his trip to India. There is also information on his presidency with the American Association for the Advancement of Sciences and his presidency of the Smith College Board of Trustees of Biological Abstracts.

Materials relating to the operation of the Smith College Genetics Experiment Station are found in the records of the Office of the President.