Margaret Storrs was born June 29, 1900 to Lucius S. Storrs and Mary Cooper Storrs in Denver, Colorado. Her mother was the daughter of Job Adams Cooper, governor of Colorado (1889-1891) and had grown up in the whirl of social, business and political life in Denver and Colorado. Mr. Storrs was a business administrator who spent most of his life with rail transportation companies in the United States. The Storrs family was originally from Connecticut.

From the time of her birth until 1907 her family's life centered on Denver, Colorado and Bozeman, Montana. However Mr. Storrs advancement in the rail industry took the family to Boston, Massachusetts in February 1907 with the family eventually living in Brookline by July 1907. They then moved to Springfield, Massachusetts in October 1908, where her brother Lucius S., Jr. was born on December 10, 1910. Another job advancement found the family moving to New Haven, Connecticut in 1911 where her parents remained until after Ms. Storrs had graduated from Smith College. The family traveled frequently to visit the extended family by automobile and railroad, especially visits to Denver, Colorado.

Ms. Storrs entered Smith College in 1918 and graduated A.B. in 1922. She did graduate work at Bryn Mawr College and she studied at University College of the University of London from 1924-1925. From 1925-1930 she taught philosophy at Bryn Mawr while completing her dissertation and graduated with the Ph.D. in 1930.

In 1930 Ms. Storrs returned to Northampton, Massachusetts and by the mid-1930s purchased a home at 66 Massasoit Street that she shared with Marine Leland, who was a member of the Smith College French Department. They shared this house together until Prof. Leland's death in 1983. On December 7, 1938 Ms. Storrs married Sir Herbert Grierson in Edinburgh, Scotland. They returned to Northampton but after February 1939 until Sir Herbert's death in February 1960 they lived apart, however she continued to use the name Mrs. Margaret Storrs Grierson for the remainder of her life.

Upon her return to Smith College in 1930 until 1936 she taught philosophy. In 1940 she was appointed the college archivist and in 1942 she was given the additional duties of executive secretary of the Friends of the Smith College Library. It was as a special project of the Friends that the Sophia Smith Collection came into being. Mrs. Grierson was its first director and held all three of these positions until her retirement in 1965. In her position as head of the Sophia Smith Collection Mrs. Grierson traveled throughout the United States and the world to assemble the manuscript materials that are so important in documenting the history of women.

After her retirement in 1965 Mrs. Grierson turned her attention to an accumulation of papers inherited from her parents related to the history of her family. From the late 1960s through the 1980s Mrs. Grierson sought information on the family and wrote (unpublished) an extensive history of the Storrs family and its ancestors including the Cooper, Rankin and Barnes families. Mrs. Grierson said she was not interested in genealogy but in the documented historical facts of these families, their movements and lives in the United States.

Repeated health problems forced Mrs. Grierson to sell her 66 Massasoit Street home in the early 1990s and she took an apartment on Crescent Street in Northampton where she lived until advanced problems found her in nursing homes. She died on December 12, 1997 at the Linda Manor Extended Care Facility in Leeds, Massachusetts.