This series is comprised primarily of Little's letters to her parents and sister during the four years she studied at Smith College. Her letters mostly deal with daily life at Smith, such as academic work, sports, theatre, activities with friends, food, clothing, requests for money, and gentlemen callers, as well as glee and mandolin club concerts. She also writes about general life in Haven House, including freshman pranks, tea, and other social gatherings. There are also several telegrams that she received, and also a letter from the Office of the Physician about precautionary measures taken in response to the epidemic of Infantile Paralysis in 1916.

Little's memorabilia book ranges from 1914 to 1918 containing articles pertianing mainly to Smith College, although several mention her specifically. Also included in the series are three photographs of Little during her college career.

This series consists of miscellaneous materials that pertain to her Smith career. These include invitations to athletic events, notes to her, People's Institute papers, copies of class songs, as well as dance and report cards.

This series consists primarily of concert programs and playbills of events Little after her graduation from Smith in 1918. Also included in the series are memoirs of her 45th and 60th college reunions.