Most of the correspondence in this collection consists of copies of three long, detailed letters to her family that Spaulding wrote in June, July and October 1832. The letters concern her experiences and activities as a missionary in the Sandwich Islands (now Hawaii). She describes a severe attack of "billious colic" that she suffered during and after the voyage to the Islands. She also discusses living arrangements, provisions, the meeting house at the missionary station, her efforts to learn the language, her husband's work as a teacher in a school for men, and punishments administered for the use of "ardent spirits." In another letter written on November 23, 1897 to her nephew, H.G. Maynard, she thanks him for sending her a publication about Mount Holyoke College and expresses her appreciation for the instruction that she received from Mary Lyon at Ipswich Female Seminary.

Chronological.