Alice Seymour Browne was born on October 29, 1878, in Harpoot, Turkey to Reverend John K. Browne and Leila Kendall, Class of 1876. Browne graduated from Mount Holyoke College in 1900 and Hartford Theological Seminary in 1903. In 1905, she sailed to Tung-chou, China to work as a missionary, and was transferred to work in Peking in 1912. On November 10, 1913, she married Murray Scott Frame in Kyoto, Japan. She worked at the Women's College of Peking University for many years and became Dean of the college in 1922. In 1928, she became Dean of Residence at Mount Holyoke while on sabbatical from Peking University. Her daughter Rosamond graduated from Mount Holyoke College in 1938. Alice Browne Frame died on August 16, 1941, in Newton, Massachusetts.