This series includes 101 letters from Woolf, with an additional postcard addressed to Duncan Grant, and 39 letters from Strachey. Enclosures include a poem by Strachey (Box 1, folder 61) and a letter from Richard Aldington to Woolf (Box 2, folder 123). A few letters are also written by Leonard Woolf (Box 1, folders 45, 77, 78). The correspondence is accompanied by an autograph manuscript preface by James Strachey for the 1956 Hogarth Press edition of Letters: Virginia Woolf & Lytton Strachey (Box 1, folder 2). Of the 32 letters from Woolf not published in this edition, most are invitations written on halfpenny and penny postcards. One is illustrated with an anti-war graphic (Box 2, folder 137). Picture postcards in the collection depict Alfoxton House, Holford (Box 1, folder 46) and other landscapes in England and Europe. A portrait of George Eliot, with a caption by Virginia Woolf, illustrates a 14 May 1931 card to Strachey (Box 2, folder 143).

The correspondence begins in 1906 after Virginia's elder brother, Thoby Stephen, died of typhoid fever. The correspondence ends in 1931 when Strachey died from stomach cancer. In addition to family and friends, Woolf and Strachey discuss literature and their travels. They mention Ralph Partridge, Dora Carrington, Lady Ottoline Morrell, Henry James, Katherine Mansfield, Duncan Grant, and Vanessa and Clive Bell.

This series includes 36 letters written by Virginia Woolf about her novels and essays to editors, publishers, booksellers, private readers, and famous writers, such as Enid Bagnold, Katherine Mansfield, and Hugh Walpole. Woolf also writes to her nephew, Quentin Bell, and to a few friends, such as Vita Sackville-West, about illness, furniture, clothes, and the dangers of traveling by automobile and airplane. A series of letters to Angus Davidson, an employee of the Hogarth Press, describe Woolf's travels in Cornwall, Greece, and Italy via Holland and Germany. There are also ten letters to Robert and Mela Spira, who were Austrian refugees during World War II (Box 2, folder 164). Woolf wrote an affidavit for Robert Spira who was interned on the Isle of Man. A 1931 letter to the book dealer, Mr. Wilson, asks for a complete set of Macaulay's works. Woolf also writes to a bibliographer of Leslie Stephen about her father's work (Box 2, folder 167).

Boxes 3-5 hold series III., Manuscripts by Virginia Woolf, which is arranged alphabetically by title.

Box 5 holds series IV., Hogarth Press Ephemera, which is arranged chronologically by item number from A Checklist of the Hogarth Press by J. Howard Woolmer

This series includes a letter from Anne Thackeray Ritchie to Mr. Darwin (probably one of the sons of Charles Darwin). Ritchie's letter discusses the declining health of Leslie Stephen, who died in 1904. In addition, the series contains a holograph draft by Arnold Bennett, "Books and Persons," which is a review of The Common Reader, Mrs. Dalloway, and Jacob's Room. The review appeared in the Evening Standard on 2 December 1926 under the title "Another Criticism of the New School." The other manuscripts in this series are letters written by Richard Aldington, James Strachey, Lytton Strachey, and Leonard Woolf which are housed in Series I.

The only original work in this series is the 1923 framed photograph of Virginia Woolf at Garsington (box 7, folder 204). The other two photographs are modern reprints.