The collection contains a body of correspondence to Perkins with letters from individuals well known in his field at the time. Letters are included from Edwin E. Bliss (AC 1837, 4 letters), Harrison Gray Otis Dwight (10), Fidelia Fiske (8), William Goodell (8), Cyrus Hamlin (4), Elias Riggs (AC 1829, 3), William G. Schauffler (10), Benjamin Schneider (AC 1830, 8), Horatio Southgate (7), and William S. Tyler (AC 1830, 8). This collection also contains eighteen manuscript sermons by Perkins, a few lectures and notes, some newspaper clippings and pamphlets, and some bound manuscripts - mostly letters and journals.

This collection is organized into five series:

1. Correspondence
2. Sermons, Lectures and Notes
3. Printed Materials
4. Photographs
5. Bound Manuscripts